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Egg Donation

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It is the High Complexity Assisted Reproduction technique that involves In vitro Fertilization (IVF) with donor eggs and has the highest success rate for achieving pregnancy.

All donations come from young women (average age between 20 to 27 years old), not infertile and healthy undergoing full interrogation to rule out metabolic diseases. They also take complete psychological and physical examination emphasizing the absence of female reproductive tract disorders. Finally, it takes a screening to rule out infectious diseases, as well as a chromosome study. All of this is done before being accepted into our program. Donors have all physical and racial characteristics.

The donation is anonymous and altruistic.

All women have a biological clock that determines when it will be their cessation of reproductive function. The ideal reproductive age ranges from 18-35 years. After this age a decline in ovarian function begins. It is reflected in the decrease in the quantity and quality of the eggs. So the possibility of achieving pregnancy spontaneously decreases and after 38 years the chances decrease significantly, even with assisted reproduction techniques of high complexity. Upon reaching 42 years of age the possibility of pregnancy is lower than 5%, so the alternative in these patients is egg donation.

This program has been designed with the aim of providing better coordination and better rates of success at national and international level. Egg donation is the assisted reproduction technique that involves high complexity in vitro fertilization (IVF) with donor eggs and has the highest success rate for achieving pregnancy.

All donations of eggs come from anonymous young not infertile women (average age between 18-27 years old), healthy who undergo a complete examination to rule out metabolic disorders as well as psychological studies, complete physical examination emphasizing the absence of female reproductive tract disorders. Finally, a screening to rule out infectious diseases and a chromosomal study is conducted. All of this is done before being accepted into our program with donors of all physical and racial characteristics. The donation is anonymous and altruistic.

There are two variants regarding egg donation:

Bank of oocytes: Eggs that are frozen at -196 degrees Celsius and come from the same donors mentioned above and that have been kept in quarantine for six months for repeat studies to donors and to corroborate that are completely healthy. Once these eggs are found to come from completely healthy women, they are released to be used.

Fresh donation: The procedure is done as an organ donation; it is freshly made and it is required that the recipient and donor are previously synchronized in their menstrual cycles.

In the case of using eggs from the Bank, it is required to do IVF with ICSI because the thawed oocytes show more resistance to be fertilized naturally.

In the case of fresh egg donation, the donor is constantly monitored to detect problems and serological tests are repeated every six months.

1.- Women without ovarian activity:

Menopause.
Premature ovarian failure.

2.- Women with ovarian activity:

Advanced reproductive age.
Repeated IVF failures.
Surrogate of hereditary diseases.
Ovarian endometriosis with severe disease.

Methodology:

Recipients (patients): Patients undergo a match and coordination through a special program with the donor that has the most similar in terms of physical characteristics and blood group to subsequently initiate contraception for better coordination of both the donor cycle and the recipient. The recipient receives the application of a GnRH analogue to block ovarian function in women with ovarian case without this analogue activity in menopausal women. With the next rule after the contraceptive use, and endometrial preparation with estrogens starts, 10-12 days after the start of estrogen vaginal ultrasound is performed to evaluate endometrial thickness and a blood estradiol to check that the absorption is adequate. According to this assessment it was decided to change the dose of estrogen or make a new control; if the results are satisfactory only wait for the donor to be ready for egg retrieval.

Donor: ovarian stimulation begins the second day of their cycle with injectable hormones to stimulate their ovaries and get an adequate amount of eggs. Approximately on the 12th day, the eggs are extracted and subjected to fertilization with the sperm of the recipient couple; the next day fertilization is evaluated and the embryos are kept in a special culture for later transferring maximum 2 embryos on day 3 of development or well blastocyst stage (day 5-6 of embryo development).

Results:
Success rates range from 65-75% per cycle performed. These percentages may be affected if there is a disturbance at the level of semen.

In Biofertility Center we have the best doctors specialized in egg donation programs therefore efficiency is reflected in obtaining the pregnancy as soon as possible.